" /> Amiodarone - CISMeF





Preferred Label : Amiodarone;

NCIt synonyms : Amiodarone Base;

NCIt definition : An iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.;

UNII : N3RQ532IUT;

InChIKey : IYIKLHRQXLHMJQ-UHFFFAOYSA-N;

CAS number : 1951-25-3;

Chemical formula : C25H29I2NO3;

ChEBI ID : CHEBI:2663;

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10/05/2025


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