" /> Amiodarone Hydrochloride - CISMeF





Preferred Label : Amiodarone Hydrochloride;

NCIt synonyms : Amiodarone;

NCIt definition : The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.;

Alternative definition : NCI-GLOSS: A drug used to treat certain types of abnormal heart rhythms that have not gotten better with other drugs. Amiodarone hydrochloride affects the electrical activity of the heart. It is a type of antiarrhythmic agent.;

UNII : 976728SY6Z;

InChIKey : ITPDYQOUSLNIHG-UHFFFAOYSA-N;

CAS number : 19774-82-4;

Drug name : Nexterone; Cordarone;

Chemical formula : C25H29I2NO3.ClH;

NSC code : 85442;

Codes from synonyms : CDR0000642962;

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30/05/2025


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