Preferred Label : Tranylcypromine Sulfate;
NCIt synonyms : 1-Amino-2-phenylcyclopropane Sulfate; ( -)-Trans-2-Phenylcyclopropylamine Sulfate (2:1);
NCIt definition : The sulfate salt form of tranylcypromine, an orally bioavailable, nonselective, irreversible,
non-hydrazine inhibitor of both monoamine oxidase (MAO) and lysine-specific demethylase
1 (LSD1/BHC110), with antidepressant and anxiolytic activities, and potential antineoplastic
activities. Upon oral administration, tranylcypromine exerts its antidepressant and
anxiolytic effects through the inhibition of MAO, an enzyme that catalyzes the breakdown
of the monoamine neurotransmitters serotonin, norepinephrine, epinephrine and dopamine.
This increases the concentrations and activity of these neurotransmitters. Tranylcypromine
exerts its antineoplastic effect through the inhibition of LSD1. Inhibition of LSD1
prevents the transcription of LSD1 target genes. LSD1, a flavin-dependent monoamine
oxidoreductase and a histone demethylase, is upregulated in a variety of cancers and
plays a key role in tumor cell proliferation, migration, and invasion.;
UNII : 7ZAT6ES870;
InChIKey : BKPRVQDIOGQWTG-KAVFMPKWSA-N;
CAS number : 13492-01-8;
Drug name : Parnate;
Chemical formula : 2C9H11N.H2SO4;
ChEBI ID : CHEBI:9653;
Origin ID : C61980;
UMLS CUI : C0304369;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
