Preferred Label : Tranylcypromine;
NCIt definition : An orally bioavailable, nonselective, irreversible, non-hydrazine inhibitor of both
monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1/BHC110), with antidepressant
and anxiolytic activities, and potential antineoplastic activities. Upon oral administration,
tranylcypromine exerts its antidepressant and anxiolytic effects through the inhibition
of MAO, an enzyme that catalyzes the breakdown of the monoamine neurotransmitters
serotonin, norepinephrine, epinephrine and dopamine. This increases the concentrations
and activity of these neurotransmitters. Tranylcypromine exerts its antineoplastic
effect through the inhibition of LSD1. Inhibition of LSD1 prevents the transcription
of LSD1 target genes. LSD1, a flavin-dependent monoamine oxidoreductase and a histone
demethylase, is upregulated in a variety of cancers and plays a key role in tumor
cell proliferation, migration, and invasion.;
UNII : 3E3V44J4Z9;
InChIKey : AELCINSCMGFISI-DTWKUNHWSA-N;
CAS number : 155-09-9; 95-62-5;
Molecule name : SKF 385;
Chemical formula : C9H11N;
NSC code : 80664;
ChEBI ID : CHEBI:9652;
Codes from synonyms : 01583;
Origin ID : C61979;
UMLS CUI : C0040778;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
