" /> Palonosetron - CISMeF





Preferred Label : Palonosetron;

NCIt synonyms : 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one;

NCIt definition : A carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB).;

Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Palonosetron is a type of serotonin receptor antagonist and a type of antiemetic.;

UNII : 5D06587D6R;

InChIKey : CPZBLNMUGSZIPR-NVXWUHKLSA-N;

CAS number : 135729-56-5;

Chemical formula : C19H24N2O;

Codes from synonyms : CDR0000616147; 382;

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01/06/2025


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