Preferred Label : Palonosetron Hydrochloride;
NCIt synonyms : 1H-Benz(de)isoquinolin-1-one, 2-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2,3,3a,4,5,6-hexahydro-,
Monohydrochloride,(3aS)-; palonosetron HCl;
NCIt related terms : Aloxi;
NCIt definition : The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin
receptor antagonist with antiemetic activity. Palonosetron competitively blocks the
action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal
afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced
nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface
of the medulla oblongata at the caudal end of the fourth ventricle and outside the
blood-brain barrier (BBB).;
Alternative definition : NCI-GLOSS: A drug used to treat nausea and vomiting caused by cancer treatment. It
is a type of serotonin receptor antagonist and a type of antiemetic.;
UNII : 23310D4I19;
InChIKey : OLDRWYVIKMSFFB-SSPJITILSA-N;
CAS number : 135729-62-3;
Drug name : Aloxi;
Molecule name : RS 25259-197;
Chemical formula : C19H24N2O.HCl;
Codes from synonyms : CDR0000584178; CDR0000476307;
Origin ID : C47650;
UMLS CUI : C1310734;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
