Halobetasol - CISMeF

Preferred Label : Halobetasol;

NCIt definition : A synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via the corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.;

UNII : 9P6159HM7T;

CAS number : 98651-66-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 98651-66-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C22H27ClF2O4;

Details

Origin ID

C61781;

UMLS CUI

C0082787;

Currated CISMeF NLP mapping
- Halobetasol (substance) [SNOMED CT concept]
- halobetasol [MeSH concept]
- halobetasol [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Halobetasol (substance) [SNOMED CT concept]
- Product containing halobetasol (medicinal product) [SNOMED CT concept]
- halobetasol [MeSH concept]
- halobetasol [MeSH Supplementary Concept]
- ulobetasol [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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