Preferred Label : Halobetasol;
NCIt definition : A synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor
activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact
with cytoplasmic corticosteroid receptors located in both the dermal and intradermal
cells, thereby activating gene expression of anti-inflammatory proteins mediated via
the corticosteroid receptor response element. Specifically, this agent induces phospholipase
A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting
the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes.
As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous
effects on vascular dilation and permeability.;
UNII : 9P6159HM7T;
CAS number : 98651-66-2;
Chemical formula : C22H27ClF2O4;
Origin ID : C61781;
UMLS CUI : C0082787;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
