Preferred Label : Halobetasol Propionate;
NCIt synonyms : 21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
17-propionate;
NCIt definition : The propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory,
antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses
across cell membranes to interact with cytoplasmic corticosteroid receptors located
in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory
proteins mediated via corticosteroid receptor response element. Specifically, this
agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic
acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such
as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema,
and pruritus through its cutaneous effects on vascular dilation and permeability.;
UNII : 91A0K1TY3Z;
InChIKey : BDSYKGHYMJNPAB-LICBFIPMSA-N;
CAS number : 66852-54-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 66852-54-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Ultravate;
Chemical formula : C25H31ClF2O5;
Origin ID : C47553;
UMLS CUI : C0098735;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
