Escitalopram - CISMeF

Preferred Label : Escitalopram;

NCIt synonyms : (S)-Citalopram; S( )-Citalopram;

NCIt definition : The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding.;

Alternative definition : NCI-GLOSS: A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs).;

UNII : 4O4S742ANY;

InChIKey : WSEQXVZVJXJVFP-FQEVSTJZSA-N;

CAS number : 128196-01-0;

Drug name : Seroplex;

Chemical formula : C20H21FN2O;

ChEBI ID : CHEBI:36791;

Codes from synonyms : CDR0000450105;

Details

Origin ID

C61754;

UMLS CUI

C1099456;

Automatic exact mappings (from CISMeF team)
- Citalopram [LOINC component]
- citalopram [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Escitalopram [MeSH Descriptor]
- Escitalopram [LOINC component]
- Escitalopram (substance) [SNOMED CT concept]
- Product containing escitalopram (medicinal product) [SNOMED CT concept]
- escitalopram [ATC Code]
- escitalopram [Substance BNPC]
- escitalopram [MeSH concept]
Validated automatic mappings to BTNT
- escitalopram [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Escitalopram Oxalate [NCIt concept]
has_target
- Sodium-Dependent Serotonin Transporter [NCIt concept]
is_free_acid_or_base_form_of
- Escitalopram Oxalate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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