Diltiazem - CISMeF

Preferred Label : Diltiazem;

NCIt synonyms : Diltazem;

NCIt definition : A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues. Alternatively, it has been suggested that this agent also interferes with the release of calcium from the sarcoplasmic reticulum and inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The overall low calcium levels leads to dilatation of the main coronary and systemic arteries and decreasing myocardial contractility, decreased peripheral arterial resistance, improved oxygen delivery to the myocardial tissue, and decreased cardiac output.;

UNII : EE92BBP03H;

InChIKey : HSUGRBWQSSZJOP-RTWAWAEBSA-N;

CAS number : 42399-41-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 42399-41-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C22H26N2O4S;

ChEBI ID : CHEBI:101278;

Codes from synonyms : 30307;

Details

Origin ID

C61725;

UMLS CUI

C0012373;

Automatic exact mappings (from CISMeF team)
- Diltiazem [ICHI extension code]
- diltiazem [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Diltiazem [ICD-11 Extension code]
- Diltiazem (substance) [SNOMED CT concept]
- Product containing diltiazem (medicinal product) [SNOMED CT concept]
- dilTIAZem [LOINC component]
- diltiazem [ATC Code]
- diltiazem [ATC Code]
- diltiazem [Substance BNPC]
- diltiazem [SNOMED Notion]
- diltiazem [MeSH concept]
- diltiazem [MeSH Descriptor]
Validated automatic mappings to BTNT
- diltiazem [ATC Code]
- diltiazem [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Diltiazem Hydrochloride [NCIt concept]
- Diltiazem Malate [NCIt concept]
is_free_acid_or_base_form_of
- Diltiazem Hydrochloride [NCIt concept]
- Diltiazem Malate [NCIt concept]

Keyword's position in hierarchy(ies) :

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