NCIt definition : A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem
blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the
ion-control gating mechanisms, thereby preventing calcium levels increase by other
revenues. Alternatively, it has been suggested that this agent also interferes with
the release of calcium from the sarcoplasmic reticulum and inhibits the influx of
extracellular calcium across both the myocardial and vascular smooth muscle cell membranes.
The overall low calcium levels leads to dilatation of the main coronary and systemic
arteries and decreasing myocardial contractility, decreased peripheral arterial resistance,
improved oxygen delivery to the myocardial tissue, and decreased cardiac output.;