Diltiazem Malate

Preferred Label : Diltiazem Malate;

NCIt synonyms : 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1);

NCIt definition : A malate salt of diltazem, a benzothiazepine calcium channel blocking agent. Diltiazem inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.;

UNII : 14Y6444DRP;

InChIKey : IUSFTUWHKCSCDY-QTKZZPNDSA-N;

CAS number : 144604-00-2;

Drug name : Tiamate;

Chemical formula : C22H26N2O4S.C4H6O5;

Details

Origin ID

C47493;

UMLS CUI

C0282138;

Automatic exact mappings (from CISMeF team)
- diltiazem [MeSH Descriptor]
Currated CISMeF NLP mapping
- Diltiazem malate [SMS substance]
- diltiazem malate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- diltiazem malate [MeSH concept]
Validated automatic mappings to NTBT
- diltiazem [MeSH Descriptor]
- diltiazem [Substance BNPC]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Diltiazem [NCIt concept]
is_salt_form_of
- Diltiazem [NCIt concept]

Keyword's position in hierarchy(ies) :

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