Diltiazem Hydrochloride

Preferred Label : Diltiazem Hydrochloride;

NCIt synonyms : Diltiazem HCl;

NCIt definition : A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04);

UNII : OLH94387TE;

InChIKey : HDRXZJPWHTXQRI-BHDTVMLSSA-N;

CAS number : 33286-22-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 33286-22-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Cardizem;

Chemical formula : C22H26N2O4S.HCl;

ChEBI ID : CHEBI:645509;

Codes from synonyms : 32070;

Details

Origin ID

C398;

UMLS CUI

C0700579;

Automatic exact mappings (from CISMeF team)
- diltiazem [MeSH Descriptor]
Currated CISMeF NLP mapping
- Diltiazem Hydrochloride [MeSH concept]
- Diltiazem hydrochloride [Substance BNPC]
- Diltiazem hydrochloride (substance) [SNOMED CT concept]
- diltiazem hydrochloride [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- diltiazem [MeSH Descriptor]
- diltiazem [Substance BNPC]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_free_acid_or_base_form
- Diltiazem [NCIt concept]
is_salt_form_of
- Diltiazem [NCIt concept]

Keyword's position in hierarchy(ies) :

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