Amlodipine - CISMeF

Preferred Label : Amlodipine;

NCIt definition : A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.;

UNII : 1J444QC288;

InChIKey : HTIQEAQVCYTUBX-UHFFFAOYSA-N;

CAS number : 88150-42-9;

Chemical formula : C20H25ClN2O5;

ChEBI ID : CHEBI:2668;

Codes from synonyms : 32073;

Details

Origin ID

C61635;

UMLS CUI

C0051696;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amlodipine (substance) [SNOMED CT concept]
- Product containing amlodipine (medicinal product) [SNOMED CT concept]
- amLODIPine [LOINC component]
- amlodipine [ATC Code]
- amlodipine [Substance BNPC]
- amlodipine [MeSH concept]
- amlodipine [MeSH Descriptor]
Validated automatic mappings to BTNT
- amlodipine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Amlodipine Besylate [NCIt concept]
- Amlodipine Maleate [NCIt concept]
is_free_acid_or_base_form_of
- Amlodipine Besylate [NCIt concept]
- Amlodipine Maleate [NCIt concept]

Keyword's position in hierarchy(ies) :

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