Amlodipine Besylate

Preferred Label : Amlodipine Besylate;

NCIt definition : The besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.;

UNII : 864V2Q084H;

InChIKey : ZPBWCRDSRKPIDG-UHFFFAOYSA-N;

CAS number : 111470-99-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 111470-99-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Norvasc;

Chemical formula : C20H25ClN2O5.C6H6O3S;

ChEBI ID : CHEBI:2669;

Details

Origin ID

C28820;

UMLS CUI

C0354468;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amlodipine Besylate [International Nonproprietary Name]
- Amlodipine Besylate [MeSH concept]
- Amlodipine besilate (substance) [SNOMED CT concept]
- amlodipine besylate [Substance BNPC]
Validated automatic mappings to NTBT
- amlodipine [MeSH Descriptor]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Amlodipine [NCIt concept]
is_salt_form_of
- Amlodipine [NCIt concept]

Keyword's position in hierarchy(ies) :

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