Amlodipine Maleate

Preferred Label : Amlodipine Maleate;

NCIt definition : The maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.;

UNII : CQ27G2BZJM;

InChIKey : TZNOWAJJWCGILX-BTJKTKAUSA-N;

CAS number : 88150-47-4;

Chemical formula : C20H25ClN2O5.C4H4O4;

Details

Origin ID

C65230;

UMLS CUI

C0886700;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amlodipine maleate (substance) [SNOMED CT concept]
- amlodipine maleate [MeSH concept]
Validated automatic mappings to NTBT
- amlodipine [Substance BNPC]
- amlodipine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Amlodipine [NCIt concept]
is_salt_form_of
- Amlodipine [NCIt concept]

Keyword's position in hierarchy(ies) :

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