Amantadine - CISMeF

Preferred Label : Amantadine;

NCIt definition : A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells. Furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.;

UNII : BF4C9Z1J53;

InChIKey : DKNWSYNQZKUICI-UHFFFAOYSA-N;

CAS number : 768-94-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 768-94-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C10H17N;

ChEBI ID : CHEBI:2618;

Details

Origin ID

C61632;

UMLS CUI

C0002403;

Automatic exact mappings (from CISMeF team)
- Amantadine [ICHI extension code]
- Antiparkinsonism drugs [ICD-10 Sub-category (who)]
False automatic mappings
- Antiparkinsonism drugs and other central muscle-tone depressants [ICD-10 Sub-category (who)]
- Poisoning by, adverse effect of and underdosing of antiparkinsonism drugs and other central muscle-tone depressants [ICD-10 Sub-category]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Amantadine [ICD-11 Extension code]
- Amantadine [LOINC component]
- Amantadine (substance) [SNOMED CT concept]
- Product containing amantadine (medicinal product) [SNOMED CT concept]
- amantadine [ATC Code]
- amantadine [Substance BNPC]
- amantadine [MeSH Descriptor]
- amantadine [MeSH concept]
- amantadine [SNOMED Notion]
Validated automatic mappings to BTNT
- amantadine [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_salt_form
- Amantadine Hydrochloride [NCIt concept]
- Amantadine Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Amantadine Hydrochloride [NCIt concept]
- Amantadine Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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