" /> Amantadine Sulfate - CISMeF





Preferred Label : Amantadine Sulfate;

NCIt definition : The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.;

UNII : 9921T5P019;

InChIKey : MYWTWSQFJLXGGQ-UHFFFAOYSA-N;

CAS number : 31377-23-8;

Chemical formula : 2C10H17N.H2O4S;

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07/05/2025


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