" /> Amantadine Hydrochloride - CISMeF





Preferred Label : Amantadine Hydrochloride;

NCIt synonyms : Amantadine HCl;

NCIt definition : The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia.;

Alternative definition : NCI-GLOSS: A drug used to treat infections caused by the influenza A virus. It blocks the ability of the virus to infect cells and to make more virus particles. It is also used to treat the symptoms of Parkinson disease. Amantidine hydrochloride is a type of antiviral agent.;

UNII : M6Q1EO9TD0;

InChIKey : WOLHOYHSEKDWQH-UHFFFAOYSA-N;

CAS number : 665-66-7;

Drug name : Symmetrel;

Chemical formula : C10H17N.ClH;

NSC code : 83653;

ChEBI ID : CHEBI:2619;

Codes from synonyms : CDR0000644726;

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30/05/2025


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