Amikacin - CISMeF

Preferred Label : Amikacin;

NCIt synonyms : Amikacin Base;

NCIt definition : A broad-spectrum semi-synthetic aminoglycoside antibiotic, derived from kanamycin with antimicrobial property. Amikacin irreversibly binds to the bacterial 30S ribosomal subunit, specifically locking 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex and misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. This agent is usually used in short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria.;

Alternative definition : NCI-GLOSS: An antibiotic drug used to treat infection. It belongs to the family of drugs called aminoglycoside antibiotics.;

UNII : 84319SGC3C;

InChIKey : LKCWBDHBTVXHDL-RMDFUYIESA-N;

CAS number : 37517-28-5;

Chemical formula : C22H43N5O13;

ChEBI ID : CHEBI:2637;

Codes from synonyms : CDR0000045174; NSC0177001;

Details

Origin ID

C61615;

UMLS CUI

C0002499;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Amikacin [ICD-11 Extension code]
- Amikacin [LOINC component]
- Amikacin (substance) [SNOMED CT concept]
- Product containing amikacin (medicinal product) [SNOMED CT concept]
- amikacin [ATC Code]
- amikacin [ATC Code]
- amikacin [ATC Code]
- amikacin [Substance BNPC]
- amikacin [MeSH Descriptor]
- amikacin [SNOMED Notion]
- amikacin [MeSH concept]
Validated automatic mappings to BTNT
- amikacin [ATC Code]
- amikacin [ATC Code]
- amikacin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Amikacin Sulfate [NCIt concept]
is_free_acid_or_base_form_of
- Amikacin Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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