Preferred Label : Licorice;
NCIt synonyms : Glycyrrhiza; Glycyrrhizae Radix;
NCIt related terms : Licorice Root Extract;
NCIt definition : An herbal extract derived from the root of the plant Glycyrrhiza glabra with potential
anti-inflammatory, antioxidant, and antineoplastic activities. Licorice root extract
contains glycoside glycyrrhizinic acid and numerous flavonoids. Glycyrrhizinic acid
in licorice root extract is hydrolyzed to glycyrrhetic acid (GA); GA inhibits 11 beta-hydroxysteroid
dehydrogenase, resulting in inhibition of the conversion of cortisol to the inactive
steroid cortisone and elevated cortisol levels. In addition, GA inhibits 17,20-lyase
and 17 beta-hydroxysteroid dehydrogenase, resulting in decreased conversions of 17-hydroxyprogesterone
to androstenedione and androstenedione to testosterone. The primary antioxidant found
in licorice root, the flavonoid glabridin, may inactivate or inhibit the activities
of some cytochrome P450 enzymes. In tumor cells, beta-hydroxy-DHP, another flavonoid,
may induce Bcl-2 phosphorylation, apoptosis, and G2/M cell cycle arrest.;
Alternative definition : NCI-GLOSS: A substance prepared from dried roots of the plant Glycyrrhiza glabra.
It is used as a flavoring in medicines, drinks, and sweets, and it is being studied
in the treatment of cancer. Licorice root extract contains several compounds that
reduce inflammation, kill certain bacteria and viruses, act like estrogen and other
hormones, and may cause cancer cells to die. It is a type of antioxidant.;
UNII : 61ZBX54883;
Codes from synonyms : CDR0000549694; 31215;
Origin ID : C61436;
UMLS CUI : C0770612;
Currated CISMeF NLP mapping
- False automatic mappings
- See also inter- (CISMeF)
- Semantic type(s)
- concept_is_in_subset
