" /> Denosumab - CISMeF





Preferred Label : Denosumab;

NCIt synonyms : Densosumab; Denosumab Biosimilar TK-006; Denosumab Biosimilar MW032; Denosumab Biosimilar QL1206;

NCIt related terms : AMG 162;

NCIt definition : A fully human monoclonal antibody directed against the receptor activator of nuclear factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease in bone resorption, and a potential increase in bone mineral density. RANKL, a protein expressed by osteoblastic cells, plays an important role in osteoclastic differentiation and activation.;

Alternative definition : NCI-GLOSS: A type of monoclonal antibody being studied in the treatment of multiple myeloma (a cancer that forms in bones) and in the prevention and treatment of bone metastases (cancer that has spread to bone from another organ). Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. AMG 162 binds to the protein RANKL and helps keep bone from breaking down.;

UNII : 4EQZ6YO2HI;

CAS number : 615258-40-7;

Drug name : Prolia; Xgeva; Ranmark;

Molecule name : AMG-162; AMG 162; TK-006;

Codes from synonyms : CDR0000514443; CDR0000535475; 154;

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31/05/2025


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