NCIt definition : A fully human monoclonal antibody directed against the receptor activator of nuclear
factor kappa beta ligand (RANKL) with antiosteoclast activity. Denosumab specifically
binds to RANKL and blocks the interaction of RANKL with RANK, a receptor located on
osteoclast cell surfaces, resulting in inhibition of osteoclast activity, a decrease
in bone resorption, and a potential increase in bone mineral density. RANKL, a protein
expressed by osteoblastic cells, plays an important role in osteoclastic differentiation
and activation.;
Alternative definition : NCI-GLOSS: A type of monoclonal antibody being studied in the treatment of multiple
myeloma (a cancer that forms in bones) and in the prevention and treatment of bone
metastases (cancer that has spread to bone from another organ). Monoclonal antibodies
are made in the laboratory and can locate and bind to substances in the body, including
cancer cells. AMG 162 binds to the protein RANKL and helps keep bone from breaking
down.;
UNII : 4EQZ6YO2HI;
CAS number : 615258-40-7;
Drug name : Prolia; Xgeva; Ranmark;
Molecule name : AMG-162; AMG 162; TK-006;
Codes from synonyms : CDR0000514443; CDR0000535475; 154;