" /> Isosorbide - CISMeF





Preferred Label : Isosorbide;

NCIt definition : An organic nitrate with vasodilator activity. Isosorbide relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle. Elevated cGMP levels in smooth muscle activate cGMP-dependent kinase activity that leads to release of sequestered Ca2 . In turn, free Ca triggers dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition isosorbide relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area.;

UNII : WXR179L51S;

InChIKey : KLDXJTOLSGUMSJ-JGWLITMVSA-N;

CAS number : 652-67-5;

Drug name : Ismotic;

Chemical formula : C6H10O4;

NSC code : 40725;

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04/05/2025


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