Isosorbide Dinitrate

Preferred Label : Isosorbide Dinitrate;

NCIt definition : The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05);

UNII : IA7306519N;

InChIKey : MOYKHGMNXAOIAT-JGWLITMVSA-N;

CAS number : 87-33-2;

Drug name : Isordil;

Chemical formula : C6H8N2O8;

NSC code : 80038;

ChEBI ID : CHEBI:6061;

Details

Origin ID

C29134;

UMLS CUI

C0022252;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Isosorbide dinitrate [ICD-11 Extension code]
- Isosorbide dinitrate (product) [Inactive SNOMED CT concept]
- Isosorbide dinitrate (substance) [SNOMED CT concept]
- Product containing isosorbide dinitrate (medicinal product) [SNOMED CT concept]
- isosorbide dinitrate [ATC Code]
- isosorbide dinitrate [ATC Code]
- isosorbide dinitrate [Substance BNPC]
- isosorbide dinitrate [MeSH concept]
- isosorbide dinitrate [SNOMED Notion]
- isosorbide dinitrate [MeSH Descriptor]
Validated automatic mappings to BTNT
- isosorbide dinitrate [ATC Code]
- isosorbide dinitrate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Isosorbide [NCIt concept]
is_salt_form_of
- Isosorbide [NCIt concept]

Keyword's position in hierarchy(ies) :

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