Isosorbide Mononitrate

Preferred Label : Isosorbide Mononitrate;

NCIt synonyms : Monosordil; 1,4:3,6-Dianhydro-D-glucitol 5-nitrate;

NCIt definition : The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05);

UNII : LX1OH63030;

InChIKey : YWXYYJSYQOXTPL-SLPGGIOYSA-N;

CAS number : 16051-77-7;

Drug name : ISMO; Imdur; Monoket;

Chemical formula : C6H9NO6;

ChEBI ID : CHEBI:6062;

Details

Origin ID

C47575;

UMLS CUI

C0064079;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Isosorbide mononitrate (product) [Inactive SNOMED CT concept]
- Isosorbide mononitrate (substance) [SNOMED CT concept]
- Product containing isosorbide mononitrate (medicinal product) [SNOMED CT concept]
- isosorbide mononitrate [ATC Code]
- isosorbide mononitrate [Substance BNPC]
- isosorbide-5-mononitrate [MeSH concept]
- isosorbide-5-mononitrate [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- isosorbide mononitrate [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Isosorbide [NCIt concept]
is_salt_form_of
- Isosorbide [NCIt concept]

Keyword's position in hierarchy(ies) :

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