Preferred Label : Leucovorin Calcium;
NCIt synonyms : 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid; 5-Formyl Tetrahydrofolate; Factor, Citrovorum; 5-Formyl-5,6,7,8-tetrahydrofolic Acid; Citrovorum Factor; Calcium Folinate; Folinic Acid Calcium Salt Pentahydrate; N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic
Acid; Folinate Calcium; Calcium (6S)-Folinate; Calcium Leucovorin; N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic
Acid, Calcium Salt (1:1); Calcium N-(p-((((6RS)-2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamate
(1:1);
NCIt related terms : folinic acid; Wellcovorin; leucovorin;
NCIt definition : An active metabolite of folic acid (also called folinic acid and citrovorum factor),
which does not require metabolism by dihydrofolate reductase, the molecular target
of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the
toxic effects of these medications, 'rescuing' the patient while permitting the antitumor
activity of the folate antagonist. This agent also potentiates the effects of fluorouracil
and its derivatives by stabilizing the binding of the drug's metabolite to its target
enzyme, thus prolonging drug activity. (NCI04);
Alternative definition : NCI-GLOSS: A drug used to lessen the toxic effects of substances that block the action
of folic acid, especially the anticancer drug methotrexate. Leucovorin calcium is
used to treat some types of anemia and is also used with fluorouracil to treat colorectal
cancer. It is also being studied in the treatment of other types of cancer and other
conditions. Leucovorin calcium is a form of folic acid. It is a type of chemoprotective
agent and a type of chemosensitizing agent.;
UNII : RPR1R4C0P4;
InChIKey : KVUAALJSMIVURS-ZEDZUCNESA-L;
CAS number : 1492-18-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1492-18-8
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G-SRS /a ;
Drug name : Rescufolin; Citrec; Folinac; Folix; Emovis; Adinepar; Folidan; Divical; Folinvit; Folidar; FOLI-cell; Foliben; Folaxin; Calinat; Citofolin; Lederfolin; Imo; Calfolex; Cehafolin; Disintox; Flynoken A; Folinoral; Rescuvolin; Lederfolat; Tonofolin; Foliplus; Calcifolin; Leucosar; Dalisol; Folaren; Wellcovorin; Ecofol; Cromatonbic Folinico;
NSC code : 3590;
Codes from synonyms : CDR0000613203; CDR0000613202; CDR0000613205; CDR0000613207; CDR0000045750; 229;
Origin ID : C607;
UMLS CUI : C0731033;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_component_of_chemotherapy_regimen
- is_salt_form_of
