NCIt definition : Human CBFB wild-type allele is located in the vicinity of 16q22.1 and is approximately
72 kb in length. This allele, which encodes core-binding factor subunit beta protein,
plays a role in the mediation of transcription. Acute myeloid leukemia of the M4Eo
subtype is linked to the occurrence of a chromosomal inversion inv(16)(p13;q22), which
fuses this gene to the MYH11 gene.;
NCIt note : Alternative splicing of the CBFB gene generates two mRNA variants, each encoding a
distinct carboxyl terminus. (Entrez Gene);