Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11

Preferred Label : Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11;

NCIt synonyms : Acute Myeloid Leukemia with Abnormal Marrow Eosinophils; Acute Myeloid Leukemia, CBFB-MYH11; Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB::MYH11; Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB::MYH11 Fusion; Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 Fusion; Acute Myeloid Leukemia, CBF-beta/MYH11;

NCIt related terms : AML with inv(16)(p13q22) or t(16;16) (p13.1;q22), (CBFB/MYH11); AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11;

NCIt definition : An acute myeloid leukemia with monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow. This type of acute myeloid leukemia has a favorable prognosis. (WHO, 2001);

Alternative definition : NICHD: Acute myeloid leukemia characterized by the presence of abnormal bone marrow eosinophils and the characteristic cytogenetic abnormality inv(16)(p13.1q22) or t(16;16)(p13.1;q22), which results in the expression of the fusion protein CBFB-MYH11. This is seen in 7-9% of children with AML.;

Neoplastic status : Malignant;

ICD-O code : 9871/3;

Details

Origin ID

C9287;

UMLS CUI

C5395080;

Automatic exact mappings (from CISMeF team)
- Acute myeloid leukemia with CBFB::MYH11 fusion (disorder) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Acute myeloid leukemia with CBFB::MYH11 fusion (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) [ORDO Disease]
- Acute myeloid leukemia with abnormal marrow eosinophils [ICD-O code]
Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Auer Rods Present [NCIt concept]
- Favorable Clinical Outcome [NCIt concept]
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Acute myeloid leukemia with CBFB::MYH11 fusion (disorder) [SNOMED CT concept]
- Acute myeloid leukemia with CBFB::MYH11 fusion (morphologic abnormality) [SNOMED CT concept]
- Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) [ORDO Disease]
- Acute myeloid leukemia with abnormal marrow eosinophils [ICD-O code]
- Acute myelomonocytic leukemia - eosinophilic variant (disorder) [SNOMED CT concept]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Disease Characteristics Table [NCIt concept]
- CPTAC Acute Myeloid Leukemia Baseline Form [NCIt concept]
- CPTAC Baseline Medical Forms Terminology [NCIt concept]
- CPTAC Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.1 Morphology Terminology [NCIt concept]
- Mapped ICDO3.1 Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology PT Terminology [NCIt concept]
- Mapped ICDO3.2 Morphology Terminology [NCIt concept]
- Mapped ICDO3.2 Terminology [NCIt concept]
- NCIt Neoplasm Core Terminology [NCIt concept]
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Eosinophil [NCIt concept]
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Monoblast [NCIt concept]
- Neoplastic Monocyte [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
- Neoplastic Neutrophilic Precursor [NCIt concept]
- Neoplastic Promonocyte [NCIt concept]
disease_has_finding
- Abnormal Eosinophilic Granules Present [NCIt concept]
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Blasts 20 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Bone Marrow Eosinophilia [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Neoplastic Granulocytes and Precursors 20 Percent or More of Bone Marrow Cells [NCIt concept]
- Neoplastic Monocytes and Precursors 20 Percent or More of Bone Marrow Cells [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- CBFB-MYH11 Fusion Protein Expression [NCIt concept]
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Granulocyte-Monocyte Progenitor Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- CBFB Gene [NCIt concept]
- CBFB/MYH11 Fusion Gene [NCIt concept]
- MYH11 Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- CBFB Gene [NCIt concept]
- CBFB wt Allele [NCIt concept]
- CBFB/MYH11 Fusion Gene [NCIt concept]
- MYH11 Gene [NCIt concept]
- MYH11 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients