Preferred Label : TSPAN32 wt Allele;
NCIt synonyms : TSSC6; Tumor-Suppressing STF cDNA 6; PHEMX; Tetraspanin 32 wt Allele; PHMX; Pan-Hematopoietic Expression Gene; MGC22455; PHEMX wt Allele; Tumor-Suppressing Subchromosomal Transferable Fragment CDNA 6 Gene; ART1;
NCIt definition : Human TSPAN32 wild-type allele is located in the vicinity of 11p15.5 and is approximately
16 kb in length. This allele, which encodes tetraspanin-32 protein, is involved in
tumor suppression and may play a role in hematopoietic cell function.;
NCIt note : This gene is one of several located on tumor-suppressing subtransferable fragments
from the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region.
Alterations in this region have been associated with the Beckwith-Wiedemann syndrome,
Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast
cancer. This gene is located among several imprinted genes; however, this gene, as
well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes
imprinting. This gene may play a role in malignancies and disease that involve this
region as well as hematopoietic cell function. This gene is described as a member
of the tetraspanin superfamily.;
GenBank Accession Number : NM_139024;
Origin ID : C52373;
UMLS CUI : C1705700;
OMIM relation
- Semantic type(s)
- gene_associated_with_disease
- gene_found_in_organism
- gene_in_chromosomal_location
