" /> CYP2C9 wt Allele - CISMeF





Preferred Label : CYP2C9 wt Allele;

NCIt synonyms : Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 wt Allele; CPC9; P450IIC9; P450 MP-4; P450 PB-1;

NCIt definition : Human CYP2C9 wild-type allele is located within 10q24 and is approximately 33 kb in length. This allele, which encodes cytochrome P450 2C9 protein, is involved in the metabolism of drugs and xenobiotics. Certain allelic variants of the CYP2C9 gene contribute to the poor metabolizer phenotype. Conversely, one variant allele of this gene contributes to the rapid metabolizer phenotype. Functional polymorphisms in the CYP2C9 gene are associated with colorectal cancer.;

NCIt note : The poor metabolizer phenotype is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. The rapid metabolizer phenotype is characterized by the enhanced ability to use cytochrome P450-dependent metabolic pathways for drug elimination.;

GenBank Accession Number : NM_000771;

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20/05/2024


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