Preferred Label : Atiprimod;
NCIt synonyms : Azaspirane SK&F106615; N,N-Diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine;
NCIt related terms : SK&F106615; azaspirane;
NCIt definition : An orally bioavailable small molecule belonging to the azaspirane class of cationic
amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties.
Atiprimod inhibits the phosphorylation of signal transducer and activator of transcription
3 (STAT3), blocking the signalling pathways of interleukin-6 and vascular endothelial
growth factor (VEGF) and downregulating the anti-apoptotic proteins Bcl-2, Bcl-XL,
and Mcl-1, thereby inhibiting cell proliferation, inducing cell cycle arrest, and
inducing apoptosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of certain multiple myelomas
and other advanced cancers. SK&F106615 may block the growth of tumors and may prevent
the growth of new blood vessels that tumors need to grow. SK&F106615 is a type of
signal transduction inhibitor and a type of antiangiogenesis agent.;
UNII : MG7D3QD743;
InChIKey : SERHTTSLBVGRBY-UHFFFAOYSA-N;
CAS number : 123018-47-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 123018-47-3
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : SK&F106615;
Chemical formula : C22H44N2;
Codes from synonyms : CDR0000523288; CDR0000486451; CDR0000523287;
Origin ID : C52184;
UMLS CUI : C1579206;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
