NCIt definition : The dimaleate salt form of atiprimod, an orally bioavailable small molecule belonging
to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic,
and antiangiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer
and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways
of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating
the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition
of cell proliferation, induction of cell cycle arrest, and apoptosis.;
UNII : YNU265SSR3;
InChIKey : WWCRKTZNNINNOT-SPIKMXEPSA-N;
CAS number : 183063-72-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 183063-72-1
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Semantic type(s)