NCIt definition : The dimaleate salt form of atiprimod, an orally bioavailable small molecule belonging
to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic,
and antiangiogenic activities. Atiprimod inhibits the phosphorylation of signal transducer
and activator of transcription 3 (STAT3) and AKT, blocking the signaling pathways
of interleukin-6 and vascular endothelial growth factor (VEGF) and downregulating
the anti-apoptotic proteins Bcl-2, Bcl-XL, and Mcl-1. This results in the inhibition
of cell proliferation, induction of cell cycle arrest, and apoptosis.;
Semantic type(s)