TNFRSF8 wt Allele

Preferred Label : TNFRSF8 wt Allele;

NCIt synonyms : CD30; KI-1; Tumor Necrosis Factor Receptor Superfamily, Member 8 wt Allele;

NCIt definition : Human TNFRSF8 wild-type allele is located in the vicinity of 1p36 and is approximately 81 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member 8 protein, plays a role in the modulation of both the nuclear factor kappa-B signal pathway and leukocyte transformation. The gene is involved in the activation of lymphoid cells in Hodgkin disease.;

NCIt note : The TNFRSF8 gene is expressed as two isoforms that are produced by alternative initiation. One isoform has a transmembrane domain and the other is a cytoplasmic protein. (SwissProt);

GenBank Accession Number : NM_152942;

Details

Origin ID

C51385;

UMLS CUI

C1705984;

OMIM relation
- Tumor necrosis factor receptor superfamily, member 8 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1p36 [NCIt concept]
gene_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Apoptosis [NCIt concept]
- Cell Survival [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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