CST6 wt Allele

Preferred Label : CST6 wt Allele;

NCIt synonyms : Cystatin E/M wt Allele; Cystatin M/E Gene;

NCIt definition : Human CST6 wild-type allele is located within 11q13 and is approximately 2 kb in length. This allele, which encodes cystatin M protein, is involved in the inhibition of cysteine proteases. CST6 gene expression is down-regulated in certain cancers such as breast carcinomas.;

NCIt note : The CST6 gene is a candidate tumor suppressor gene. In breast cancer cells, ectopic expression of CST6 has been shown to inhibit cell proliferation, migration, invasion and tumor growth.;

GenBank Accession Number : NM_001323;

Details

Origin ID

C51344;

UMLS CUI

C1707155;

OMIM relation
- Cystatin 6 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Breast Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 11: 65536038-65537552 [NCIt concept]
gene_in_chromosomal_location
- 11q13 [NCIt concept]
gene_plays_role_in_process
- Enzyme Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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