MOK wt Allele - CISMeF

Preferred Label : MOK wt Allele;

NCIt synonyms : RAGE wt Allele; MOK Protein Kinase wt Allele; RAGE; RAGE-1; Renal Tumor Antigen Gene; RAGE1;

NCIt definition : Human RAGE wild-type allele is located within 14q32 and is approximately 79 kb in length. This allele, which encodes MAPK/MAK/MRK overlapping kinase protein, is involved in the induction of intracellular oxidative stress and a pro-inflammatory status in response to activation by advanced glycation end products. The RAGE gene is associated with a number of neurological disorders including Parkinson's disease, familial amyloidotic polyneuropathy, and vasculitic neuropathy.;

NCIt note : The RAGE gene is putatively involved in the development of diabetic neuropathy. The RAGE pathway is proposed to play an early role in the pathogenesis of diabetic polyneuropathies prior to the onset of chronic hyperglycemia.;

GenBank Accession Number : NM_014226;

Details

Origin ID

C51275;

UMLS CUI

C3539760;

Automatic exact mappings (from CISMeF team)
- Advanced glycosylation end product-specific receptor [OMIM gene]
- Mok protein kinase [OMIM gene]
- Rabies [ORDO Disease]
- Rabies [UNVA Disease]
- Rage [MedDRA LLT]
- Receptor for Advanced Glycation End Products [MeSH Descriptor]
- rage [MeSH Descriptor]
- rage [MeSH concept]
OMIM relation
- Mok protein kinase [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 14q32 [NCIt concept]
gene_plays_role_in_process
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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