CLCA2 wt Allele

Preferred Label : CLCA2 wt Allele;

NCIt synonyms : Chloride Channel, Calcium Activated, Family Member 2 wt Allele; CaCC; Chloride Channel, Calcium-Activated, 2 Gene; CLCRG2;

NCIt definition : Human CLCA2 wild-type allele is located within1p31-p22 and is approximately 32 kb in length. This allele, which encodes chloride channel protein, may play a role in cellular adhesion and has also been implicated as a tumor suppressor gene for breast cancer.;

NCIt note : The A2 gene (CLCA family) at 1p31-p22 produces a 3.6 kb transcript in trachea and mammary gland, in addition to lung. The encoded Calcium-Activated Chloride Channel-2 is 51% identical to human CLCA1 and displays an outward rectifying conductance of anions.;

GenBank Accession Number : NM_006536;

Details

Origin ID

C51088;

UMLS CUI

C1707135;

OMIM relation
- Chloride channel accessory 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_associated_with_disease
- Breast Carcinoma [NCIt concept]
- Cystic Fibrosis [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 86601846-86633961 [NCIt concept]
gene_in_chromosomal_location
- 1p31-p22 [NCIt concept]
gene_is_element_in_pathway
- Olfactory Transduction Pathway [NCIt concept]
gene_plays_role_in_process
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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