" /> DCK wt Allele - CISMeF





Preferred Label : DCK wt Allele;

NCIt synonyms : Deoxycytidine Kinase wt Allele;

NCIt definition : Human DCK wild-type allele is located in the vicinity of 4q13.3-q21.1 and is approximately 37 kb in length. This allele, which encodes deoxycytidine kinase protein, plays a role in the phosphorylation of certain deoxyribonucleosides and their nucleoside analogs.;

NCIt note : The DCK gene is clinically important because of its role in therapeutic drug sensitivity. Decreased levels of deoxycytidine kinase are associated with resistance to both antiviral and anticancer nucleoside analogs. Elevated deoxycytidine kinase activity results in activation of these drugs to their corresponding cytotoxic nucleoside triphosphates. An allelic variant of the DCK gene is associated with poor response to chemotherapy in patients with acute myeloid leukemia.;

GenBank Accession Number : NM_000788;

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27/04/2024


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