" /> TREX1 wt Allele - CISMeF





Preferred Label : TREX1 wt Allele;

NCIt synonyms : DRN3; 3-Prime Repair Exonuclease 1 Gene; Aicardi-Goutieres Syndrome 1 Gene; Deoxyribonuclease III, DnaQ/MutD (E. coli)-Like Gene; HERNS; CRV; DNase III Gene; Three Prime Repair Exonuclease 1 wt Allele; 3 Prime Repair Exonuclease 1 Gene; AGS1;

NCIt definition : Human TREX1 wild-type allele is located in the vicinity of 3p21.31 and is approximately 3 kb in length. This allele, which encodes three prime repair exonuclease 1 protein, plays a role in DNA repair. Mutation of the gene is associated with Aicardi-Goutieres syndrome 1, Chilblain lupus, vasculopathy, retinal, with cerebral leukodystrophy, and increased susceptibility to systemic lupus erythematosus.;

NCIt note : GeneID 11277 was annotated as a single gene with two non-overlapping coding regions. GeneID 11277 now represents only the downstream coding region encoding three prime repair exonuclease 1 (TREX1). The upstream coding region encoding ATR-interacting protein (ATRIP) is represented by geneID 84126. (29 May 2007, EntrezGene);

GenBank Accession Number : AF151105;

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13/05/2024


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