Eculizumab - CISMeF

Preferred Label : Eculizumab;

NCIt synonyms : Monoclonal antibody 5G1.1; Immunoglobulin, Anti-(Human Complement C5 Alpha-Chain) (Human-Mouse Monoclonal 5G1.1 Heavy Chain), Disulfide with Human-Mouse Monoclonal 5G.1.1 Light Chain, Dimer; Alexion; h5G1.1; Eculizumab Biosimilar BCD-148; Eculizumab Biosimilar ABP 959; Eculizumab Biosimilar SB12;

NCIt related terms : Soliris; Eculizumab-beke; Eculizumab-epys;

NCIt definition : A humanized monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. (NCI05);

Alternative definition : NCI-GLOSS: A monoclonal antibody used to prevent red blood cells from being destroyed in patients with paroxysmal nocturnal hemoglobinuria (PNH), a red blood cell disorder. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body. Eculizumab blocks a protein in the blood that causes the breakdown of red blood cells.;

UNII : A3ULP0F556;

CAS number : 219685-50-4;

Drug name : Soliris; Elizaria;

Molecule name : SB-12; ABP-959; ABP 959; SB 12; BCD 148; BCD-148;

Codes from synonyms : CDR0000438733; CDR0000542431; 176; 122214; 122216;

Details

Origin ID

C48386;

UMLS CUI

C1541483;

Automatic exact mappings (from CISMeF team)
- Alexion [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Eculizumab [LOINC component]
- Eculizumab (substance) [SNOMED CT concept]
- Product containing eculizumab (medicinal product) [SNOMED CT concept]
- eculizumab [ATC Code]
- eculizumab [International Nonproprietary Name]
- eculizumab [MeSH Supplementary Concept]
- eculizumab [MeSH concept]
Validated automatic mappings to BTNT
- eculizumab [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Complement C5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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