NCIt definition : A humanized monoclonal antibody directed against terminal complement protein C5. Eculizumab
binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory
components and blocking the complement-mediated destruction of paroxysmal nocturnal
hemoglobinuria (PNH) red blood cells. (NCI05);
Alternative definition : NCI-GLOSS: A monoclonal antibody used to prevent red blood cells from being destroyed
in patients with paroxysmal nocturnal hemoglobinuria (PNH), a red blood cell disorder.
Monoclonal antibodies are made in the laboratory and can locate and bind to substances
in the body. Eculizumab blocks a protein in the blood that causes the breakdown of
red blood cells.;
UNII : A3ULP0F556;
CAS number : 219685-50-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 219685-50-4
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;