Valproate Sodium

Preferred Label : Valproate Sodium;

NCIt synonyms : 2-Propylpentanoic Acid Sodium Salt;

NCIt definition : The sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blood. Although the mechanism of action remains to be elucidated, valproate sodium increases concentrations of gamma-aminobutyric acid (GABA) in the brain, probably due to inhibition of the enzymes responsible for the catabolism of GABA. This potentiates the synaptic actions of GABA. Valproate sodium may also affect potassium channels, thereby creating a direct membrane-stabilizing effect.;

UNII : 5VOM6GYJ0D;

InChIKey : AEQFSUDEHCCHBT-UHFFFAOYSA-M;

CAS number : 1069-66-5;

Drug name : Ergenyl; Depacon;

Chemical formula : C8H15O2.Na;

ChEBI ID : CHEBI:9925;

Details

Origin ID

C48029;

UMLS CUI

C0037567;

Automatic exact mappings (from CISMeF team)
- Depth [LOINC component]
- Valproic acid [ICD-11 Extension code]
- valproic acid [MeSH Descriptor]
Currated CISMeF NLP mapping
- Sodium valproate [ICD-11 Extension code]
- Sodium valproate [ICHI extension code]
- Sodium valproate [SMS substance]
- Sodium valproate (substance) [SNOMED CT concept]
- Valproate sodium [Substance BNPC]
- valproate sodium [MeSH concept]
- valproate sodium [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Sodium valproate [ICD-11 Extension code]
- Sodium valproate (substance) [SNOMED CT concept]
- Valproate sodium [Substance BNPC]
- valproate sodium [MeSH concept]
- valproate sodium [SNOMED Notion]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Valproic Acid [NCIt concept]
is_salt_form_of
- Valproic Acid [NCIt concept]

Keyword's position in hierarchy(ies) :

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