Preferred Label : Ondansetron Hydrochloride;
NCIt synonyms : 4H-Carbazol-4-one, 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-,
Monohydrochloride, ( -)-, Dihydrate;
NCIt related terms : Zofran;
NCIt definition : The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative
and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor
antagonist with antiemetic activity. Although its mechanism of action has not been
fully characterized, ondansetron appears to competitively block the action of serotonin
at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally
in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting
is located, resulting in the suppression of chemotherapy- and radiotherapy-induced
nausea and vomiting.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat nausea and vomiting caused
by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.;
UNII : NMH84OZK2B;
InChIKey : VRSLTNZJOUZKLX-UHFFFAOYSA-N;
CAS number : 103639-04-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 103639-04-9
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Zofran;
Molecule name : SN-307; GR 38032F; GR-C507/75;
Chemical formula : C18H19N3O.HCl.2H2O;
NSC code : 665799;
Codes from synonyms : CDR0000413960; NSC0665799; CDR0000616146;
Origin ID : C48007;
UMLS CUI : C0700478;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
