Melphalan Hydrochloride

Preferred Label : Melphalan Hydrochloride;

NCIt synonyms : 3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride;

NCIt related terms : Alkeran;

NCIt definition : A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard. Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or death.;

Alternative definition : NCI-GLOSS: A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.;

UNII : 1VXP4V453T;

InChIKey : OUUYBRCCFUEMLH-YDALLXLXSA-N;

CAS number : 3223-07-2;

Drug name : Alkerana; Alkeran; Evomela; Hepzato;

Chemical formula : C13H18Cl2N2O2.HCl;

NSC code : 241286;

Codes from synonyms : CDR0000413941;

Origin ID

C48002;

UMLS CUI

C0771055;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Melphalan hydrochloride (substance) [SNOMED CT concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Melphalan [NCIt concept]
is_component_of_chemotherapy_regimen
- Melphalan Regimen [NCIt concept]
is_salt_form_of
- Melphalan [NCIt concept]

Keyword's position in hierarchy(ies) :

Details

Main resources

You can consult :