NCIt definition : A bifunctional alkylating agent and phenylalanine derivative of nitrogen mustard.
Melphalan hydrochloride is converted into highly reactive ethylenimmonium intermediates
that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine
N3 of DNA. This agent also alkylates RNA and protein structures. As a result RNA transcription
and protein synthesis are inhibited, ultimately leading to cell growth arrest and/or
death.;
Alternative definition : NCI-GLOSS: A drug that is used to treat multiple myeloma and ovarian epithelial cancer
and is being studied in the treatment of other types of cancer. It belongs to the
family of drugs called alkylating agents.;
UNII : 1VXP4V453T;
InChIKey : OUUYBRCCFUEMLH-YDALLXLXSA-N;
CAS number : 3223-07-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 3223-07-2
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