" /> Tolcapone - CISMeF





Preferred Label : Tolcapone;

NCIt synonyms : 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone; Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-;

NCIt definition : A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa.;

UNII : CIF6334OLY;

InChIKey : MIQPIUSUKVNLNT-UHFFFAOYSA-N;

CAS number : 134308-13-7;

Drug name : Tasmar;

Chemical formula : C14H11NO5;

ChEBI ID : CHEBI:63630;

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31/05/2025


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