NCIt definition : A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone
selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism
of biologically active catechols and their hydroxylated metabolites by transferring
the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing
substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor
and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy-
L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability
and enhancement of delivery to the central nervous system (CNS) of levodopa.;