NCIt definition : A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone
selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism
of biologically active catechols and their hydroxylated metabolites by transferring
the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing
substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor
and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy-
L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability
and enhancement of delivery to the central nervous system (CNS) of levodopa.;
UNII : CIF6334OLY;
InChIKey : MIQPIUSUKVNLNT-UHFFFAOYSA-N;
CAS number : 134308-13-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 134308-13-7
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