Tolcapone - CISMeF

Preferred Label : Tolcapone;

MeSH definition : A benzophenone and nitrophenol compound that acts as an inhibitor of CATECHOL O-METHYLTRANSFERASE, an enzyme involved in the metabolism of DOPAMINE and LEVODOPA. It is used in the treatment of PARKINSON DISEASE in patients for whom levodopa is ineffective or contraindicated.;

MeSH hyponym : Ro 40 7592; Ro 407592; Ro-40-7592; Ro407592;

Related MeSH term : 3,4 Dihydroxy 5' methyl 5 nitrobenzophenone;

MeSH CAS label : Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-;

MeSH Related Number : 134308-13-7 (Tolcapone);

UNII : CIF6334OLY;

Details

Origin ID

D000077867;

UMLS CUI

C0246330;

ATC code(s)
- tolcapone [ATC Code]
ATC code(s)
- tolcapone [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
MeSH indexing information
- catechol O-Methyltransferase [MeSH Descriptor]
Pharmacological action(s)
- Catechol O-Methyltransferase Inhibitors [MeSH Descriptor]
Record concept(s)
- 3,4-Dihydroxy-5'-methyl-5-nitrobenzophenone [MeSH concept]
- SOM0226 [MeSH concept]
- ro 40-7592 [MeSH concept]
- tasmar [MeSH concept]
- tolcapone [MeSH concept]
See also inter- (CISMeF)
- Product containing tolcapone (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to BTNT
- tolcapone [ATC Code]

Keyword's position in hierarchy(ies) :

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