Preferred Label : Hydroxyzine Hydrochloride;
NCIt synonyms : 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine Hydrochloride;
NCIt related terms : HYDROXYZINE DIHYDROCHLORIDE;
NCIt definition : The hydrochloride salt form of hydroxyzine, a piperazine histamine H1-receptor antagonist
with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties.
Hydroxyzine hydrochloride blocks the H1 histamine receptor and prevents the symptoms
that are caused by histamine activity on capillaries, bronchial smooth muscle, and
gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability,
bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle.
In addition, hydroxyzine hydrochloride crosses the blood-brain barrier and acts on
the histamine H1-receptors in the central nervous system. (NCI05);
UNII : 76755771U3;
InChIKey : ANOMHKZSQFYSBR-UHFFFAOYSA-N;
CAS number : 2192-20-3;
Drug name : Anxanil; Hyzine-50; Atarax;
Chemical formula : C21H27ClN2O2.2HCl;
ChEBI ID : CHEBI:5819;
Origin ID : C47559;
UMLS CUI : C0600110;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
