" /> Diphtheria Toxin - CISMeF





Preferred Label : Diphtheria Toxin;

NCIt related terms : DIPHTHERIA TOXIN (CORYNEPHAGE BETA);

NCIt definition : An exotoxin protein encoded by a bacteriophage that infects Corynebacterium diphtheriae (C. diphtheriae) and is the causative agent for the pathology associated with diphtheria. C. diphtheriae secretes a single chain protein toxin that is quickly cleaved into two fragments (the A and B subunits) that are linked by disulfide bridges. The B subunit binds to the plasma membrane of a host cell and forms a pore that allows the catalytic A subunit to be internalized. Once in the cytoplasm, the catalytic domain of the toxin moiety dissociates from the B subunit and catalyzes the transfer of the ADP-ribose moiety of NAD to a diphthamide residue of elongation factor 2 (EF-2). This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in an inhibition of protein synthesis and, subsequently, cell death.;

UNII : 8LV40J44ZI;

CAS number : 1523010-93-6;

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08/05/2025


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