diphtheria toxin

Preferred Label : diphtheria toxin;

MeSH definition : An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.;

MeSH synonym : corynebacterium diphtheriae toxin; toxin, corynebacterium diphtheriae;

MeSH annotation : /antag permitted but consider also DIPHTHERIA ANTITOXIN;

Wikipedia link : https://en.wikipedia.org/wiki/Diphtheria toxin;

Is substance : O;

Details

Origin ID

D004167;

UMLS CUI

C0012550;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Toxin, diphtheria (Schick Test) [ICHI extension code]
- Toxin, diphtheria (Schick Test) [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Corynebacterium diphtheriae toxin [LOINC component]
- Diphtheria Toxin [NCIt concept]
- Diphtheria toxin (substance) [SNOMED CT concept]
- diphtheria toxin [SNOMED Notion]
Indexing information
- CRM197 (non-toxic variant of diphtheria toxin) [MeSH Supplementary Concept]
- CRM45 fragment of diphtheria toxin [MeSH Supplementary Concept]
- CRM9 protein, bacteria [MeSH Supplementary Concept]
Pharmacological action(s)
- poisons [MeSH Descriptor]
Record concept(s)
- diphtheria toxin [MeSH concept]
Related MeSH Supplementary Concept(s)
- CRM 107 [MeSH Supplementary Concept]
- CRM 288 [MeSH Supplementary Concept]
- DAB(389) interleukin-7 [MeSH Supplementary Concept]
- DAB(389)-(Gly(4)-Ser)2-interleukin 3 [MeSH Supplementary Concept]
- DAB(389)-GRP fusion protein, recombinant [MeSH Supplementary Concept]
- DAB(389)-interleukin 4 [MeSH Supplementary Concept]
- DAB(389)-interleukin 6 [MeSH Supplementary Concept]
- DAB(486)-interleukin 2 [MeSH Supplementary Concept]
- DT 2219 immunotoxin [MeSH Supplementary Concept]
- DT390-anti-CD3sFv [MeSH Supplementary Concept]
- DTctGMCSF protein, recombinant [MeSH Supplementary Concept]
- E7777 fusion protein [MeSH Supplementary Concept]
- FN18-CRM9 [MeSH Supplementary Concept]
- GD5 protein, recombinant [MeSH Supplementary Concept]
- IT-87 immunotoxin [MeSH Supplementary Concept]
- VEGF121-diphtheria toxin conjugate [MeSH Supplementary Concept]
- denileukin diftitox [MeSH Supplementary Concept]
- diphtheria toxin fragment A [MeSH Supplementary Concept]
- diphtheria toxin fragment B [MeSH Supplementary Concept]
- diphtheria toxin-interleukin-3 fusion protein, recombinant [MeSH Supplementary Concept]
- diphtheria toxin-related-alpha-melanocyte-stimulating hormone fusion toxin [MeSH Supplementary Concept]
- diphtheria toxin-related-murine interleukin-4-fusion toxin [MeSH Supplementary Concept]
- dt(388) granulocyte-macrophage colony-stimulating factor [MeSH Supplementary Concept]
- human chorionic gonadotropin-diphtheria toxin fragment A [MeSH Supplementary Concept]
- hybrid toxin, diphtheria-cholera [MeSH Supplementary Concept]
- insulin crosslinked to the catalytic fragment A of diphtheria toxin [MeSH Supplementary Concept]
- interleukin 2-diphtheria toxin [MeSH Supplementary Concept]
- transferrin-diphtheria toxin conjugate [MeSH Supplementary Concept]
See also
- corynebacterium diphtheriae [MeSH Descriptor]
- diphtheria toxoid [MeSH Descriptor]
See also (suggested by CISMeF)
- diphtheria [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Corynebacterium diphtheriae toxin [LOINC component]
- Diphtheria Toxin [NCIt concept]
- Diphtheria toxin [LOINC component]
- Diphtheria toxin (substance) [SNOMED CT concept]
- diphtheria toxin [SNOMED Notion]

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