NCIt synonyms : Atypical Fibroxanthoma of the Skin; Atypical Cutaneous Fibroxanthoma; Atypical Skin Fibroxanthoma; Superficial Malignant Fibrous Histiocytoma; Atypical Fibroxanthoma of Skin; AFX; Skin Malignant Fibrous Histiocytoma; Malignant Fibrous Histiocytoma of Skin;
NCIt related terms : Atypical fibrous histiocytoma;
NCIt definition : An intermediate cutaneous mesenchymal neoplasm of uncertain differentiation, usually
affecting the actinic-damaged skin of the elderly. The tumor presents as a single
cutaneous nodule which is often ulcerated. Microscopically, it is characterized by
the presence of highly atypical cytologic features, pleomorphism and abundant mitotic
figures. The vast majority of patients have an excellent prognosis following conservative
therapy. Recurrences are infrequent, and metastasis is rare.;