Riboadenylate Transferase

Preferred Label : Riboadenylate Transferase;

NCIt synonyms : Polynucleotide Adenylyltransferase;

NCIt definition : Nuclear or cytoplasmic human Riboadenylate Transferases (Poly A Polymerase Family) catalyze template-independent post-transcriptional extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity during eukaryotic mRNA maturation. The N-terminal region appears required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. (NCI);

Details

Origin ID

C41038;

UMLS CUI

C5441722;

Currated CISMeF NLP mapping
- Polynucleotide adenylyltransferase (substance) [SNOMED CT concept]
- polynucleotide adenylyltransferase [SNOMED Notion]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Polynucleotide adenylyltransferase (substance) [SNOMED CT concept]
- polynucleotide adenylyltransferase [MeSH Descriptor]
- polynucleotide adenylyltransferase [SNOMED Notion]
- polynucleotide adenylyltransferase [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Polymerase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Polymerization [NCIt concept]
- RNA Polyadenylation [NCIt concept]
- RNA Synthesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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