Interleukin 3 Receptor

Preferred Label : Interleukin 3 Receptor;

NCIt synonyms : IL-3 Receptor; Interleukin-3 Receptor; IL3 Receptor;

NCIt definition : Heterodimeric human Interleukin 3 Receptor is composed of 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha and GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain. IL3RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Receptor binding to IL3 depends on the signal transducing beta subunit, common to the high affinity IL3-, IL5- and GM-CSF receptors. (NCI);

Details

Origin ID

C39273;

UMLS CUI

C5441741;

Currated CISMeF NLP mapping
- receptors, Interleukin-3 [MeSH concept]
- receptors, interleukin-3 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- receptors, Interleukin-3 [MeSH concept]
- receptors, interleukin-3 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Recombinant Interleukin-3 [NCIt concept]
gene_product_has_biochemical_function
- Cytokine Receptor [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Cell Activation Process [NCIt concept]
- Immune Response Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Daniplestim [NCIt concept]

Keyword's position in hierarchy(ies) :

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