Recombinant Interleukin-3

Preferred Label : Recombinant Interleukin-3;

NCIt synonyms : Erythrocyte Burst-Promoting Factor; MCGF; Mast-Cell Colony-Stimulating Factor; IL-3; Interleukin-3; Multipotential Colony-Stimulating Factor; Eosinophil-Mast Cell Growth-Factor; Colony-Stimulating Factor 2 Alpha; Therapeutic Interleukin-3;

NCIt definition : A recombinant form of interleukin-3, a cytokine produced by activated T-cells and mast cells involved in intercellular communication, hematopoiesis, and inflammation. IL-3 binds and activates specific receptors on hematopoietic cells and in the nervous system, triggering expression of specific genes via the Ras signaling pathway and through Jak2 activation. This agent stimulates the proliferation of pluripotent hematopoietic progenitor cells.;

Molecule name : ILE-964;

NSC code : 641115;

Details

Origin ID

C588;

UMLS CUI

C1527130;

Automatic exact mappings (from CISMeF team)
- interleukin-3 receptor binding [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Interleukin 3 Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Gene Regulation Process [NCIt concept]
- Hematopoiesis Induction [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Intercellular Communication Induction [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Etoposide/Interleukin-3 [NCIt concept]
- Carboplatin/Interleukin-3 [NCIt concept]
- Cisplatin/Etoposide/Filgrastim/Ifosfamide/Interleukin-3 [NCIt concept]
- Cisplatin/Filgrastim/Ifosfamide/Interleukin-3/Vinblastine [NCIt concept]
- Cyclophosphamide/Doxorubicin/Fluorouracil/Interleukin-3/Leucovorin Calcium [NCIt concept]
- Cyclophosphamide/Doxorubicin/Fluorouracil/Interleukin-3/Leucovorin Calcium/Sargramostim [NCIt concept]
- Cyclophosphamide/Doxorubicin/Interleukin-3/Prednisone/Vincristine/Zidovudine [NCIt concept]
- Cyclophosphamide/Interleukin-3/Sargramostim [NCIt concept]
- Cytarabine/Daunorubicin/Etoposide/Interleukin-3 [NCIt concept]
- Cytarabine/Idarubicin/Interleukin-3 [NCIt concept]
- Cytarabine/Interleukin-3 [NCIt concept]
- Epoetin Alfa/Filgrastim/Flt3 Ligand/Interleukin-3/Sargramostim [NCIt concept]
- Epoetin Alfa/Interleukin-3 [NCIt concept]
- Etoposide/Ifosfamide/Interleukin-3 [NCIt concept]
- Interleukin-3/Melphalan [NCIt concept]
- Interleukin-3/Thiotepa [NCIt concept]
- Interleukin-3/Zidovudine [NCIt concept]
- interleukin-3/interleukin-6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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